ATL-146e
ATL-146e is a selective adenosine receptor antagonist that is used in scientific research. It is a derivative of adenosine, a naturally occurring chemical in the body that has various effects, including promoting sleep and suppressing arousal. ATL-146e is used to study the role of adenosine receptors in the body and has been used in studies investigating conditions such as inflammation, ischemia, and cancer.
Chemistry[edit | edit source]
ATL-146e is a derivative of adenosine, which is a purine nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. It is a selective antagonist for the adenosine A2A receptor, meaning it blocks the action of adenosine at this receptor without affecting other adenosine receptors.
Pharmacology[edit | edit source]
ATL-146e has been shown to reduce inflammation and tissue damage in animal models of conditions such as ischemia and reperfusion injury. It is thought to work by blocking the action of adenosine at the A2A receptor, which is involved in the regulation of inflammation and immune responses.
Research[edit | edit source]
Research into ATL-146e has focused on its potential use in conditions where inflammation and tissue damage are a problem, such as ischemia and reperfusion injury. It has also been investigated for potential use in cancer treatment, as adenosine A2A receptors have been found to be overexpressed in some types of cancer.
See also[edit | edit source]
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