Acecainide

From WikiMD.com Medical Encyclopedia

A medication used in the treatment of cardiac arrhythmias


Acecainide, also known as N-acetylprocainamide (NAPA), is a pharmaceutical drug used primarily in the management of certain types of cardiac arrhythmias. It is a metabolite of the antiarrhythmic drug procainamide.

Pharmacology[edit | edit source]

Acecainide is classified as a Class III antiarrhythmic agent. It works by blocking potassium channels in the heart, which prolongs the action potential and refractory period of cardiac cells. This action helps to stabilize the heart rhythm and prevent abnormal electrical activity.

Metabolism[edit | edit source]

Acecainide is formed in the body from procainamide through the action of the enzyme N-acetyltransferase 2 (NAT2). This enzyme acetylates procainamide, converting it into acecainide. The rate of this conversion can vary among individuals due to genetic differences in NAT2 activity.

Chemical structure of Acecainide
N-acetyltransferase 2 enzyme

Clinical Use[edit | edit source]

Acecainide is used in the treatment of ventricular arrhythmias, such as ventricular tachycardia and ventricular fibrillation. It is particularly useful in patients who have developed arrhythmias following a myocardial infarction.

Electrophysiological Effects[edit | edit source]

Acecainide affects the electrical conduction system of the heart by prolonging the QT interval on the electrocardiogram (ECG). This can be visualized in the EKG complex.

Electrocardiogram complex showing the QT interval

Adverse Effects[edit | edit source]

The use of acecainide can lead to several side effects, including hypotension, bradycardia, and proarrhythmia. It is important to monitor patients closely for these effects, especially in those with pre-existing heart conditions.

Related pages[edit | edit source]

Gallery[edit | edit source]

WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD