Acecainide

Acecainide (also known as N-acetylprocainamide and NAPA) is a pharmacological agent that is primarily used as an antiarrhythmic agent. It is a metabolite of procainamide, another antiarrhythmic drug. Acecainide works by slowing the rate at which the heart beats, and is used to treat conditions such as atrial fibrillation and ventricular tachycardia.

Pharmacology

Acecainide is classified as a Class III antiarrhythmic agent, which means it works by blocking the potassium channels in the heart. This action prolongs the duration of the action potential, thereby slowing the heart rate. Acecainide is also known to have Class I antiarrhythmic properties, which means it can also work by blocking sodium channels.

Clinical Use

Acecainide is used in the treatment of various types of cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. It is also used in the management of premature ventricular contractions (PVCs), a common type of arrhythmia.

Side Effects

Like all medications, acecainide can cause side effects. The most common side effects include nausea, vomiting, and diarrhea. Less common side effects can include dizziness, headache, and fatigue. In rare cases, acecainide can cause serious side effects such as heart block, ventricular fibrillation, and torsades de pointes.

Contraindications

Acecainide is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with severe heart failure, as it can worsen the condition.

See Also

• Procainamide
• Antiarrhythmic agent
• Atrial fibrillation
• Ventricular tachycardia