Acetylglycinamide

Acetylglycinamide is an organic compound with the formula C4H8N2O2. It is a derivative of glycinamide, which is a non-proteinogenic amino acid. Acetylglycinamide is used in the synthesis of various pharmaceuticals.

Structure and properties

Acetylglycinamide is a white crystalline solid. It is soluble in water and has a melting point of 187-189 °C. The compound has a molecular weight of 116.12 g/mol. It is a derivative of glycinamide, which is a non-proteinogenic amino acid. The compound is acetylated on the nitrogen atom of the amide group.

Synthesis

Acetylglycinamide can be synthesized from glycinamide by acetylation with acetic anhydride. The reaction is typically carried out in a solvent such as dichloromethane or ethyl acetate.

Applications

Acetylglycinamide is used in the synthesis of various pharmaceuticals. It is a key intermediate in the synthesis of acetohydroxamic acid, a drug used to treat urinary tract infections. It is also used in the synthesis of glycinex, a drug used to treat epilepsy.

Safety

As with all chemicals, acetylglycinamide should be handled with care. It may cause irritation to the skin and eyes, and may be harmful if swallowed or inhaled.

See also

• Glycinamide
• Acetohydroxamic acid
• Glycinex

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