Acridine carboxamide
Acridine Carboxamide[edit | edit source]
Acridine carboxamide is a synthetic compound that belongs to the class of acridine derivatives. It is primarily studied for its potential use in cancer therapy due to its ability to intercalate into DNA and inhibit topoisomerase enzymes, which are crucial for DNA replication and transcription.
Chemical Structure[edit | edit source]
Acridine carboxamide is characterized by its acridine core, which is a planar, tricyclic structure. The carboxamide group is attached to the acridine moiety, enhancing its ability to interact with DNA. The chemical structure of acridine carboxamide is depicted in the adjacent image.
Mechanism of Action[edit | edit source]
Acridine carboxamide exerts its effects by intercalating between the base pairs of DNA. This intercalation disrupts the normal function of DNA, inhibiting the activity of topoisomerase I and II enzymes. These enzymes are responsible for relieving torsional strain in DNA during replication and transcription. By inhibiting these enzymes, acridine carboxamide can induce DNA damage and apoptosis in rapidly dividing cancer cells.
Therapeutic Applications[edit | edit source]
Acridine carboxamide has been investigated for its potential use in treating various types of cancer, including leukemia, lymphoma, and solid tumors. Its ability to target DNA and interfere with cell division makes it a promising candidate for chemotherapy. However, its clinical use is limited by potential toxicity and the development of drug resistance.
Research and Development[edit | edit source]
Ongoing research is focused on improving the efficacy and safety profile of acridine carboxamide. Modifications to its chemical structure aim to enhance its selectivity for cancer cells and reduce side effects. Additionally, combination therapies with other anticancer agents are being explored to overcome resistance mechanisms.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
