Adavosertib
Adavosertib[edit | edit source]
Adavosertib is a small molecule inhibitor of the WEE1 kinase, which plays a crucial role in the regulation of the cell cycle. It is being investigated for its potential use in the treatment of various types of cancer.
Mechanism of Action[edit | edit source]
Adavosertib functions by inhibiting the activity of the WEE1 kinase. WEE1 is a key regulator of the G2/M checkpoint in the cell cycle. By inhibiting WEE1, adavosertib prevents the phosphorylation of cyclin-dependent kinase 1 (CDK1), leading to the premature entry of cells into mitosis. This can result in mitotic catastrophe and apoptosis in cancer cells, particularly those with defective p53 pathways.
Clinical Development[edit | edit source]
Adavosertib is currently undergoing clinical trials for its efficacy in treating various cancers, including ovarian cancer, breast cancer, and colorectal cancer. It is often studied in combination with other chemotherapeutic agents to enhance its anticancer effects.
Pharmacokinetics[edit | edit source]
The pharmacokinetic profile of adavosertib includes its absorption, distribution, metabolism, and excretion. It is administered orally and has been shown to have a favorable bioavailability. The drug is metabolized primarily in the liver and excreted through the kidneys.
Side Effects[edit | edit source]
Common side effects of adavosertib include nausea, diarrhea, fatigue, and hematological toxicity. These side effects are generally manageable with supportive care and dose adjustments.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
