Adenosine A2B receptor

Adenosine A2B receptor is a protein that in humans is encoded by the ADORA2B gene. It is one of the four known types of adenosine receptors, along with A1, A2A, and A3. The A2B receptor is a member of the G protein-coupled receptor superfamily.

Function

The adenosine A2B receptor is responsible for mediating numerous physiological responses to adenosine, a ubiquitous nucleoside that plays crucial roles in biochemistry and cell biology. These responses include vasodilation, inhibition of neutrophil degranulation in neutrophilic inflammation, and production of interleukin IL-4 and interleukin IL-13 in Th2 cells.

Clinical significance

The A2B receptor has been implicated in a variety of diseases, including asthma, ischemia, and cancer. It is also involved in inflammatory responses and the regulation of blood pressure. In the context of disease, the A2B receptor can either promote or inhibit inflammation, depending on the specific pathological condition.

Pharmacology

Several drugs have been developed to target the A2B receptor, including antagonists and agonists. These drugs have potential therapeutic applications in the treatment of various diseases, such as chronic obstructive pulmonary disease (COPD), asthma, and cancer.

See also

• Adenosine receptor
• G protein-coupled receptor
• Adenosine

References

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