Aflatoxicol
Aflatoxicol is a mycotoxin that is a metabolite of aflatoxin B1, produced by certain species of Aspergillus fungi, particularly Aspergillus flavus and Aspergillus parasiticus. Aflatoxicol is known for its toxic and carcinogenic properties, posing significant health risks to humans and animals.
Chemical Structure and Properties[edit | edit source]
Aflatoxicol is a reduced form of aflatoxin B1, characterized by the presence of a hydroxyl group. Its chemical structure is similar to that of aflatoxin B1, but it is less potent in terms of toxicity. The molecular formula of aflatoxicol is C17H14O6.
Biosynthesis[edit | edit source]
Aflatoxicol is formed in the liver of animals and humans through the reduction of aflatoxin B1 by the enzyme aflatoxin B1 reductase. This metabolic process is part of the body's attempt to detoxify aflatoxin B1, although aflatoxicol itself retains some level of toxicity.
Health Effects[edit | edit source]
Exposure to aflatoxicol, like other aflatoxins, can lead to various health issues. It is known to cause hepatotoxicity, which can result in liver damage. Chronic exposure to aflatoxicol has been linked to an increased risk of liver cancer. Additionally, aflatoxicol can impair the immune system, making individuals more susceptible to infections.
Detection and Analysis[edit | edit source]
The detection of aflatoxicol in food and biological samples is crucial for assessing exposure and preventing health risks. Analytical methods such as high-performance liquid chromatography (HPLC) and mass spectrometry (MS) are commonly used to identify and quantify aflatoxicol levels.
Regulation and Safety[edit | edit source]
Due to its toxic nature, the presence of aflatoxicol in food and feed is regulated by various health authorities, including the Food and Drug Administration (FDA) and the World Health Organization (WHO). These regulations set maximum allowable limits for aflatoxins, including aflatoxicol, to ensure food safety.
Related Pages[edit | edit source]
- Aflatoxin
- Aspergillus flavus
- Aspergillus parasiticus
- Mycotoxin
- Hepatotoxicity
- Liver cancer
- High-performance liquid chromatography
- Mass spectrometry
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