Afoxolaner

Afoxolaner is an insecticide and acaricide that belongs to the isoxazoline group. It is used in veterinary medicine for the treatment and prevention of flea and tick infestations in dogs.

Etymology[edit | edit source]

The term "Afoxolaner" is a compound word derived from parts of the names of its chemical constituents. However, the exact etymology is not known.

Pharmacology[edit | edit source]

Afoxolaner acts as an antagonist at ligand-gated chloride channels in the nervous system of insects and acarines. It particularly affects channels activated by the neurotransmitter gamma-aminobutyric acid (GABA), resulting in uncontrolled activity and death of the parasite.

Uses[edit | edit source]

Afoxolaner is used in dogs for the treatment and prevention of flea and tick infestations. It is administered orally and its effects last for at least one month. It is also used in combination with other drugs for the treatment of other parasitic infections.

Safety[edit | edit source]

Afoxolaner is generally safe for use in dogs. However, it can cause side effects such as vomiting, diarrhea, and lack of appetite. It should not be used in dogs with a known hypersensitivity to afoxolaner.

See also[edit | edit source]

Afoxolaner Resources
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