Algestone acetonide

Algestone acetonide is a synthetic, steroidal progestin that is used in medicine. It is a derivative of progesterone and is specifically a progestogen, which is a type of hormone. Algestone acetonide is used in hormone replacement therapy and for the treatment of gynecological disorders.

History

Algestone acetonide was first described in the literature in 1964. It was introduced for medical use by 1965.

Medical uses

Algestone acetonide is used in combination with estradiol (a type of estrogen) in the treatment of menopausal symptoms and osteoporosis. It is also used in the treatment of endometriosis, uterine fibroids, and menorrhagia (heavy menstrual bleeding).

Pharmacology

As a progestin, algestone acetonide has progestogenic effects. It binds to and activates the progesterone receptor, which mediates its effects. Algestone acetonide has high affinity for the progesterone receptor and is a potent progestogen.

Side effects

Possible side effects of algestone acetonide include menstrual irregularities, weight gain, breast tenderness, and mood changes. It can also cause nausea, vomiting, and headache.

Society and culture

Algestone acetonide is marketed under a number of brand names including Duralutin, Prodox, and Synophase. It is available as an oral tablet and as an injection.

See also

• List of progestogens
• List of steroidal progestogens