Alpha-2C adrenergic receptor
Alpha-2C adrenergic receptor (ADRA2C) is a G protein-coupled receptor that is encoded by the ADRA2C gene in humans. This receptor is part of the adrenergic receptor family, which plays a crucial role in the sympathetic nervous system.
Function[edit | edit source]
The Alpha-2C adrenergic receptor is a subtype of the alpha-2 adrenergic receptor, which mediates the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. This receptor is found in the brain and cardiovascular system, where it regulates the release of neurotransmitter and controls the dilation and constriction of blood vessels.
Clinical significance[edit | edit source]
Mutations in the ADRA2C gene have been associated with various disorders, including hypertension, congestive heart failure, and schizophrenia. In addition, drugs that target the Alpha-2C adrenergic receptor, such as clonidine and yohimbine, are used in the treatment of these conditions.
Pharmacology[edit | edit source]
The Alpha-2C adrenergic receptor is a target for several types of drugs, including alpha-2 adrenergic agonists and alpha-2 adrenergic antagonists. These drugs can either stimulate or inhibit the receptor, respectively, leading to various therapeutic effects.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
