Alpha-2B adrenergic receptor
Alpha-2B adrenergic receptor (ADRA2B) is a G protein-coupled receptor associated with the sympathetic nervous system. It is a subtype of the alpha-2 adrenergic receptor, which has three main types: alpha-2A, alpha-2B, and alpha-2C.
Function[edit | edit source]
The alpha-2B adrenergic receptor is involved in regulating neurotransmitter release from adrenergic neurons in the central nervous system. It is also involved in the regulation of smooth muscle contraction and platelet aggregation.
Clinical significance[edit | edit source]
Alterations in the function of the alpha-2B adrenergic receptor have been implicated in a variety of conditions, including hypertension, mental disorders, and drug addiction.
Pharmacology[edit | edit source]
Several drugs target the alpha-2B adrenergic receptor, including clonidine, dexmedetomidine, and tizanidine. These drugs are used to treat conditions such as hypertension, anxiety disorders, and muscle spasticity.
Genetics[edit | edit source]
The gene encoding the alpha-2B adrenergic receptor is located on chromosome 2 in humans. Variations in this gene have been associated with differences in drug response and susceptibility to certain diseases.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
