Alpha-Hydroxyetizolam

Alpha-Hydroxyetizolam is a benzodiazepine analog and a major metabolite of etizolam. It is formed in the body after consumption of etizolam, and is believed to be responsible for much of the drug's effects.

Pharmacology

Alpha-Hydroxyetizolam, like other benzodiazepine analogs, acts as a positive allosteric modulator at the GABA_A receptor. This enhances the effect of the neurotransmitter GABA, leading to sedative and anxiolytic effects. It is thought to be less potent than etizolam itself, but is present in higher concentrations and for longer periods of time in the body, contributing significantly to the overall effects of the drug.

Metabolism

Alpha-Hydroxyetizolam is formed in the liver by the enzyme CYP3A4, which oxidizes etizolam to form the alpha-hydroxy derivative. This metabolite is then further metabolized, primarily by glucuronidation, before being excreted in the urine.

Toxicology

As a metabolite of etizolam, alpha-hydroxyetizolam is likely to share many of the same risks and side effects. These can include drowsiness, confusion, and dependence with long-term use. However, the specific toxicology of alpha-hydroxyetizolam has not been extensively studied.

See also

• Etizolam
• Benzodiazepine
• Metabolite
• GABA_A receptor

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