Alprazolam triazolobenzophenone

Alprazolam triazolobenzophenone is a pharmaceutical compound used in the synthesis of Alprazolam, a medication primarily used for the treatment of anxiety disorders and panic disorder. Alprazolam triazolobenzophenone is a key intermediate in the production of Alprazolam, and its synthesis and use are critical to the production of this important medication.

Synthesis

The synthesis of Alprazolam triazolobenzophenone involves several steps, starting with the reaction of benzophenone with propionic acid to form a propionyl derivative. This is then reacted with hydrazine to form a hydrazone derivative, which is then cyclized with phosphorus oxychloride to form the triazolobenzophenone. This compound is then used in the final steps of the synthesis of Alprazolam.

Use in Alprazolam Production

Alprazolam triazolobenzophenone is a critical intermediate in the production of Alprazolam. It is reacted with 2-amino-5-chlorobenzophenone in the presence of phosphorus pentasulfide to form Alprazolam. This reaction is typically carried out in a suitable solvent such as dichloromethane or toluene.

Safety and Handling

As with all pharmaceutical intermediates, Alprazolam triazolobenzophenone should be handled with care. It should be stored in a cool, dry place and protected from light. It should not be ingested or come into contact with the skin or eyes. In case of accidental exposure, seek immediate medical attention.

See Also

• Alprazolam
• Benzodiazepine
• Pharmaceutical synthesis