Amodiaquine

Information about Amodiaquine

Amodiaquine is an aminoquinoline used for the therapy of malaria. Amodiaquine has been linked to severe cases of acute hepatitis which can be fatal, for which reason it is recommended for use only as treatment and not for prophylaxis against malaria.

Mechanism of action of Amodiaquine

Amodiaquine (am" oh dye' a kwin) is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is active against the asexual erythrocytic forms of Plasmodium species. Amodiaquine is related in structure to chloroquine, and highly chloroquine-resistant P. falciparum is also resistant to amodiaquine. Amodiaquine remains a useful agent for treating falciparum malaria, but because of its potential for causing hepatotoxicity, it is no longer used for antimalarial prophylaxis. Amodiaquine is available in tablets of 150 to 600 mg in generic forms and under the brand names Camoquin and Flavoquine.

Dosage and administration for Amodiaquine

The recommended dosage is 10 mg/kg of amodiaquine base once daily for 3 days usually in combination with other antimalarial agents.

Side effects of Amodiaquine

Common side effects of amodiaquine include nausea, diarrhea, skin rash and itching.

• Dailymed label info on Amodiaquine
• FDA Amodiaquine

Amodiaquine Resources
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