Plasmodium

Plasmodium falciparum (malaria) parasite in blood

Plasmodium zyklus

Plasmodium falciparum in Red Blood Cells

Hemoglobinopathies-Slicing-the-Gordian-Knot-of-Plasmodium-falciparum-Malaria-Pathogenesis-ppat

Plasmodium is a genus of the protozoan parasites primarily known for being the causative agent of malaria. This genus comprises numerous species, several of which are responsible for causing malaria in humans.

Overview

Malaria, a life-threatening disease transmitted through the bite of infected Anopheles mosquitoes, is caused by the unicellular Plasmodium parasites. Upon entering the human bloodstream, these parasites travel to the liver where they mature and reproduce. Subsequently, they infect red blood cells, leading to the symptoms associated with malaria.

Species Infecting Humans

While the Plasmodium genus contains many species, only a select few naturally infect humans. These species include:

• Plasmodium falciparum - Responsible for the most severe form of malaria and the majority of malaria-related deaths.
• Plasmodium vivax - Known to cause a milder form of the disease but has a broader geographic distribution.
• Plasmodium ovale - Predominantly found in Western Africa, it can cause relapsing malaria.
• Plasmodium malariae - Causes a chronic infection that can persist for decades in the host.

Additionally, Plasmodium knowlesi is primarily a zoonotic species infecting macaques in Southeast Asia. However, there have been increasing reports of this species infecting humans, making it an emerging concern in the realm of public health.

Transmission and Life Cycle

The primary vector for Plasmodium species is the Anopheles mosquito. During a blood meal, an infected mosquito introduces sporozoites into the human host. These sporozoites then travel to the liver, reproduce, and invade red blood cells, leading to symptomatic disease.

Prevention and Treatment

Prevention of Plasmodium infections primarily revolves around vector control, primarily through the use of insecticide-treated mosquito nets and indoor residual spraying. Various antimalarial drugs are available to treat infections, with the choice of drug depending on the species of Plasmodium and the region's drug-resistance patterns.

See Also

• Malaria
• Protozoa
• Anopheles mosquitoes
• Antimalarial drugs

Plasmodium Resources
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