Amlexanox

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(Redirected from Amoxanox)

Amlexanox is a medication and oral paste used in the treatment of aphthous ulcers (canker sores) and inflammatory conditions. It has anti-inflammatory and antiallergic properties. Amlexanox works by inhibiting the release of histamine and leukotrienes from mast cells, basophils, and neutrophils, thereby reducing inflammation and promoting healing of ulcers.

Medical Uses[edit | edit source]

Amlexanox is primarily used for the treatment of recurrent minor aphthous ulcers in patients with a normal immune system. It is applied directly to the ulcerated area and can help reduce the pain and duration of the ulcers.

Mechanism of Action[edit | edit source]

The exact mechanism of action of amlexanox is not fully understood. However, it is known to act as an inhibitor of several inflammatory cytokines, including tumor necrosis factor alpha (TNF-α) and interleukin-1 (IL-1), which are involved in the inflammatory process. By inhibiting these cytokines, amlexanox reduces inflammation and accelerates healing.

Side Effects[edit | edit source]

The most common side effects of amlexanox include:

Pharmacokinetics[edit | edit source]

Information on the pharmacokinetics of amlexanox is limited. However, when applied topically, systemic absorption is minimal, reducing the risk of systemic side effects.

History[edit | edit source]

Amlexanox was first approved for medical use in Japan in the 1980s. Since then, it has been approved in several other countries for the treatment of aphthous ulcers.

Research[edit | edit source]

Research into amlexanox has also explored its potential use in treating other conditions, such as asthma, allergic rhinitis, and even obesity and diabetes, due to its anti-inflammatory effects. However, these uses are still under investigation and are not yet approved.


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