Andrew Marks

American physician and scientist

Andrew R. Marks is an American physician and scientist known for his pioneering research in the field of cardiology and muscle physiology. He is a prominent figure in the study of calcium signaling and its implications in heart disease and muscular dystrophy.

Early life and education

Andrew Marks was born in the United States. He pursued his undergraduate studies at Columbia University, where he developed an interest in the biological sciences. He later attended Harvard Medical School, earning his MD degree. During his medical training, Marks became fascinated with the mechanisms of muscle contraction and the role of calcium ions in cellular processes.

Career

Marks began his career as a researcher focusing on the molecular mechanisms underlying cardiac and skeletal muscle function. He joined the faculty at Columbia University College of Physicians and Surgeons, where he has held various academic and administrative positions. Marks is currently the Chair of the Department of Physiology and Cellular Biophysics at Columbia University.

Andrew R. Marks, MD

Research contributions

Andrew Marks is best known for his work on the ryanodine receptor, a critical calcium release channel in muscle cells. His research has elucidated how dysregulation of this receptor can lead to heart failure and arrhythmias. Marks discovered that "leaky" ryanodine receptors contribute to heart disease by causing calcium to leak from the sarcoplasmic reticulum into the cytoplasm, disrupting normal cardiac function.

Marks' work has also extended to muscular dystrophy, where he has explored how similar mechanisms of calcium dysregulation can lead to muscle degeneration. His research has opened new avenues for potential therapeutic interventions targeting calcium channels to treat these conditions.

Awards and honors

Throughout his career, Andrew Marks has received numerous awards and honors for his contributions to medical science. He is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. His work has been recognized with prestigious awards such as the Lasker Award and the Gairdner Foundation International Award.

Personal life

Andrew Marks is married and has children. He is known for his dedication to mentoring young scientists and fostering a collaborative research environment. Outside of his professional life, Marks enjoys classical music and hiking.

Related pages

• Calcium signaling
• Ryanodine receptor
• Heart failure
• Muscular dystrophy