AndroGel

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AndroGel

Drug Information
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AndroGel is a brand name for a topical gel formulation of testosterone, a steroid hormone responsible for the development and maintenance of male sexual characteristics and secondary sexual traits. It is primarily used in the treatment of male hypogonadism, a condition where the body does not produce enough testosterone.

Medical uses

AndroGel is indicated for replacement therapy in males for conditions associated with a deficiency or absence of endogenous testosterone:

• Primary hypogonadism (congenital or acquired)
• Hypogonadotropic hypogonadism (congenital or acquired)

Administration

AndroGel is applied topically to the skin, which allows testosterone to be absorbed through the skin and into the bloodstream. It is typically applied once daily to clean, dry, and intact skin on the shoulders, upper arms, or abdomen.

Side effects

The use of AndroGel can lead to side effects, some of which are common to all testosterone therapies. These include:

• Skin irritation at the site of application
• Increased red blood cell count
• Changes in cholesterol levels
• Increased risk of prostate abnormalities
• Potential for promoting existing prostate cancer
• Changes in liver function tests

Contraindications

AndroGel should not be used by individuals with known hypersensitivity to testosterone or any of its excipients. It is also contraindicated in men with breast cancer or known or suspected prostate cancer.

Pharmacology

Mechanism of action

Testosterone, the active ingredient in AndroGel, binds to and activates specific nuclear receptors, leading to modulation of gene expression and changes in protein synthesis which are responsible for its androgenic and anabolic effects.

Pharmacokinetics

The pharmacokinetics of testosterone when delivered by AndroGel are characterized by a sustained increase in serum testosterone levels within the normal range with once-daily application.

Regulatory information

AndroGel is classified as a prescription drug in many countries and is regulated by health authorities to ensure its safety and efficacy in the indicated populations.

See also

• Testosterone therapy
• Hormone replacement therapy (male)
• Steroid hormone