Androgen-binding protein

Androgen-binding protein (ABP) is a protein that is produced in the Sertoli cells of the testes and plays a crucial role in the male reproductive system. It is responsible for maintaining high levels of androgens in the seminiferous tubules, which is necessary for spermatogenesis.

Function

ABP binds to testosterone and dihydrotestosterone in the testes, increasing their concentration in the seminiferous tubules and promoting the maturation of spermatozoa. This is essential for male fertility.

Structure

The structure of ABP is similar to that of sex hormone-binding globulin (SHBG), and they are both members of the serine protease inhibitor (serpin) superfamily. However, ABP has a higher affinity for dihydrotestosterone than SHBG.

Clinical significance

Abnormal levels of ABP can lead to various health issues. Low levels can result in infertility due to impaired spermatogenesis, while high levels can lead to hyperandrogenism.

See also

• Sex hormone-binding globulin
• Sertoli cell
• Androgen
• Spermatogenesis

References

Androgen-binding protein Resources
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