Androgen-binding protein
Androgen-binding protein (ABP) is a protein that is produced in the Sertoli cells of the testes and plays a crucial role in the male reproductive system. It is responsible for maintaining high levels of androgens in the seminiferous tubules, which is necessary for spermatogenesis.
Function[edit | edit source]
ABP binds to testosterone and dihydrotestosterone in the testes, increasing their concentration in the seminiferous tubules and promoting the maturation of spermatozoa. This is essential for male fertility.
Structure[edit | edit source]
The structure of ABP is similar to that of sex hormone-binding globulin (SHBG), and they are both members of the serine protease inhibitor (serpin) superfamily. However, ABP has a higher affinity for dihydrotestosterone than SHBG.
Clinical significance[edit | edit source]
Abnormal levels of ABP can lead to various health issues. Low levels can result in infertility due to impaired spermatogenesis, while high levels can lead to hyperandrogenism.
See also[edit | edit source]
References[edit | edit source]
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