Transcortin
Transcortin, also known as corticosteroid-binding globulin (CBG) or serpin A6 is a protein that in humans is encoded by the SERPINA6 gene. It is an alpha-2 globulin that binds corticosteroids in the bloodstream and transports them to target tissues.
Function[edit | edit source]
Transcortin binds several steroid hormones at high rates, including cortisol, corticosterone, progesterone, and aldosterone. However, it has a particular affinity for cortisol, hence its alternative name, corticosteroid-binding globulin. The primary function of transcortin is to transport cortisol from the adrenal gland to target tissues and cells across the body.
Structure[edit | edit source]
Transcortin is a single-chain glycoprotein with a molecular weight of approximately 52,000. It is a member of the serpin family of proteins, which are known for their serine protease inhibitor activity, although transcortin does not exhibit this property.
Clinical significance[edit | edit source]
Abnormal levels of transcortin can lead to various health issues. Low levels can result in an excess of free cortisol, leading to Cushing's syndrome. Conversely, high levels can lead to a deficiency of free cortisol, potentially causing Addison's disease.
See also[edit | edit source]
References[edit | edit source]
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