Angiotensin IV

Angiotensin IV is a peptide that is part of the RAS, a hormone system that regulates blood pressure and fluid balance. It is derived from the degradation of Angiotensin II, a potent vasoconstrictor.

Structure and Function

Angiotensin IV is a hexapeptide, meaning it is composed of six amino acids. Its sequence is Val-Tyr-Ile-His-Pro-Phe, which is the same as the last six amino acids of Angiotensin II.

Angiotensin IV has been found to have several functions. It is a potent vasodilator, meaning it can widen blood vessels and lower blood pressure. It also has effects on the central nervous system, including the ability to enhance learning and memory.

Receptors

Angiotensin IV binds to a specific receptor, known as the AT4 receptor. This receptor is found in many tissues, including the brain, heart, kidneys, and adrenal glands. Binding of Angiotensin IV to the AT4 receptor triggers a variety of cellular responses, including the release of nitric oxide, a potent vasodilator.

Clinical Significance

Angiotensin IV and its receptor have been implicated in a number of diseases, including high blood pressure, heart failure, and kidney disease. There is also evidence that they may play a role in Alzheimer's disease and other forms of cognitive impairment.

Research and Therapeutic Potential

Research into Angiotensin IV and the AT4 receptor is ongoing, with the aim of developing new treatments for diseases such as hypertension and Alzheimer's disease. Several drugs that target the AT4 receptor are currently in development.

See Also

• Angiotensin
• Renin-Angiotensin System
• Angiotensin II
• Angiotensin Receptors

References

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