Angiotensin II

From WikiMD's Wellness Encyclopedia

What is Angiotensin II?[edit | edit source]

Angiotensin II.svg
Angiotensin II 1N9V.png
ASS AngiotensinII V1.svg


What are the uses of this medicine?[edit | edit source]

This medicine is used to increases blood pressure in adults with septic or other distributive shock.

How does this medicine work?[edit | edit source]

  • Angiotensin II raises blood pressure by vasoconstriction and increased aldosterone release.
  • Direct action of angiotensin II on the vessel wall is mediated by binding to the G-protein-coupled angiotensin II receptor type 1 on vascular smooth muscle cells, which stimulates Ca 2+/calmodulin-dependent phosphorylation of myosin and causes smooth muscle contraction.

Who Should Not Use this medicine ?[edit | edit source]

  • This medcine have no usage limitations.

What drug interactions can this medicine cause?[edit | edit source]

Is this medicine FDA approved?[edit | edit source]

  • It was approved for use in the United States in 2017.

How should this medicine be used?[edit | edit source]

Recommended Dosage

  • Start GIAPREZA intravenously at 20 nanograms (ng)/kg/min.
  • Titrate as frequently as every 5 minutes by increments of up to 15 ng/kg/min as needed.
  • During the first 3 hours, the maximum dose should not exceed 80 ng/kg/min.
  • Maintenance dose should not exceed 40 ng/kg/min.
  • Doses as low as 1.25 ng/kg/min may be used.
  • Dilute GIAPREZA in 0.9% sodium chloride prior to use.
  • Diluted solution may be stored at room temperature or under refrigeration and should be discarded after 24 hours.

Administration

  • The recommended starting dosage of GIAPREZA is 20 nanograms (ng)/kg/min via continuous intravenous infusion.
  • Administration through a central venous line is recommended.
  • Monitor blood pressure response and titrate GIAPREZA as frequently as every 5 minutes by increments of up to 15 ng/kg/min as needed to achieve or maintain target blood pressure.
  • Do not exceed 80 ng/kg/min during the first 3 hours of treatment.
  • Maintenance dose should not exceed 40 ng/kg/min. Doses as low as 1.25 ng/kg/min may be used.
  • Once the underlying shock has sufficiently improved, down-titrate every 5 to 15 minutes by increments of up to 15 ng/kg/min based on blood pressure.

What are the dosage forms and brand names of this medicine?[edit | edit source]

This medicine is available in fallowing doasage form:

  • As Injection: 2.5 mg/mL in a vial.

This medicine is available in fallowing brand namesː

  • GIAPREZA

What side effects can this medication cause?[edit | edit source]

The most common side effects of this medicine include:

What special precautions should I follow?[edit | edit source]

There was a higher incidence of arterial and venous thrombotic and thromboembolic events in patients who received GIAPREZA. Use concurrent venous thromboembolism (VTE) prophylaxis.

What to do in case of emergency/overdose?[edit | edit source]

  • Overdose of GIAPREZA would be expected to result in hypertension, necessitating close monitoring and supportive care.
  • Effects are expected to be brief because the half-life of angiotensin II is less than one minute.

Can this medicine be used in pregnancy?[edit | edit source]

  • The published data on angiotensin II use in pregnant women are not sufficient to determine a drug-associated risk of adverse developmental outcomes.

Can this medicine be used in children?[edit | edit source]

  • The safety and efficacy of GIAPREZA in pediatric patients have not been established.

What are the active and inactive ingredients in this medicine?[edit | edit source]

Active ingredient:

  • ANGIOTENSIN II

Inactive ingredients:

  • MANNITOL
  • WATER
  • SODIUM HYDROXIDE
  • HYDROCHLORIC ACID

Who manufactures and distributes this medicine?[edit | edit source]

What should I know about storage and disposal of this medication?[edit | edit source]

  • GIAPREZA vials should be stored in the refrigerator (36-46°F, 2-8°C).
  • Discard prepared diluted solution after 24 hours at room temperature or under refrigeration.
Angiotensin II Resources

Contributors: Deepika vegiraju