Zofenopril
Zofenopril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used in the treatment of hypertension and ischemic heart disease. It is a prodrug, converted in the liver to the active form, zofenoprilat.
Pharmacology[edit | edit source]
Zofenopril is a sulfhydryl group-containing ACE inhibitor. It is a prodrug and is converted to the active metabolite zofenoprilat in the liver. The conversion is not affected by the presence of food in the stomach. Zofenoprilat inhibits the angiotensin-converting enzyme, which is involved in the conversion of angiotensin I to angiotensin II. This results in a decrease in angiotensin II, leading to a decrease in aldosterone secretion, and an increase in serum renin activity.
Clinical use[edit | edit source]
Zofenopril is used in the treatment of hypertension and ischemic heart disease. In hypertension, it is used as monotherapy or in combination with other antihypertensive agents. In ischemic heart disease, it is used in the treatment of myocardial infarction and in the prevention of heart failure.
Side effects[edit | edit source]
The most common side effects of zofenopril are cough, dizziness, and rash. Other side effects include hyperkalemia, hypotension, and renal impairment. Rarely, it can cause angioedema.
Contraindications[edit | edit source]
Zofenopril is contraindicated in patients with a history of angioedema related to previous treatment with an ACE inhibitor. It is also contraindicated in patients with bilateral renal artery stenosis, hypersensitivity to zofenopril, and in patients with a history of idiopathic angioedema.
See also[edit | edit source]
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