Tasosartan

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Tasosartan

Tasosartan is a non-peptide angiotensin II receptor antagonist that was developed for the treatment of hypertension. It is a type of antihypertensive drug that works by blocking the effects of the hormone angiotensin II, thereby helping to relax and widen blood vessels.

Pharmacology

Tasosartan is classified as an angiotensin II receptor antagonist, also known as an angiotensin receptor blocker (ARB). These drugs work by inhibiting the action of angiotensin II, a hormone that constricts blood vessels and releases another hormone called aldosterone, which promotes the retention of sodium and water in the body. By blocking the effects of angiotensin II, ARBs help to relax and dilate blood vessels, reduce the volume of blood, and lower blood pressure.

Clinical Use

Tasosartan was developed for the treatment of hypertension, a condition characterized by persistently high blood pressure. Hypertension is a major risk factor for various cardiovascular diseases, including stroke, heart attack, and heart failure. By lowering blood pressure, tasosartan can help to reduce the risk of these diseases.

Development and Approval

Tasosartan was developed by the pharmaceutical company SmithKline Beecham, now part of GlaxoSmithKline. However, it was withdrawn from the market due to concerns about its safety profile.

Safety and Side Effects

Like other ARBs, tasosartan is generally well tolerated. However, it can cause some side effects, such as dizziness, headache, and fatigue. In rare cases, it can also cause serious side effects, such as kidney failure, liver damage, and severe allergic reactions.

See Also

• Angiotensin II receptor antagonist
• Hypertension
• Antihypertensive drug