Saralasin
Saralasin is a synthetic angiotensin II antagonist and a non-peptide compound. It is used in medical research to understand the role of angiotensin II in the body. Saralasin is not used clinically due to its short half-life and the need for continuous infusion.
Pharmacology[edit | edit source]
Saralasin acts by blocking the effects of angiotensin II, a potent vasoconstrictor. It competes with angiotensin II for binding at the angiotensin II type 1 receptor (AT1), which is found in many tissues including vascular smooth muscle and the adrenal glands. By blocking the action of angiotensin II, saralasin causes vasodilation and reduces the secretion of aldosterone, a hormone that increases the reabsorption of sodium and water in the kidneys.
Clinical significance[edit | edit source]
Although saralasin is not used in clinical practice, it has been used in research to investigate the role of angiotensin II in conditions such as hypertension, heart failure, and kidney disease. Studies have shown that blocking the effects of angiotensin II can reduce blood pressure, improve heart function, and slow the progression of kidney disease.
Side effects[edit | edit source]
As with all medications, saralasin can cause side effects. The most common side effects are related to its vasodilatory effects and include flushing, headache, and hypotension. Rarely, saralasin can cause a rash or changes in liver function tests.
See also[edit | edit source]
Saralasin Resources | |
---|---|
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD