Valsartan/hydrochlorothiazide
Valsartan/hydrochlorothiazide[edit | edit source]
Valsartan/hydrochlorothiazide is a combination medication used to treat hypertension (high blood pressure). It combines two active ingredients: valsartan, an angiotensin II receptor antagonist, and hydrochlorothiazide, a thiazide diuretic.
Medical uses[edit | edit source]
Valsartan/hydrochlorothiazide is primarily prescribed for the management of hypertension. By lowering blood pressure, it helps to prevent strokes, heart attacks, and kidney problems. The combination of valsartan and hydrochlorothiazide works by relaxing blood vessels and reducing the amount of water and salt in the body.
Mechanism of action[edit | edit source]
Valsartan works by blocking the effects of angiotensin II, a substance in the body that causes blood vessels to tighten and narrow. By blocking this action, valsartan helps to relax and widen blood vessels, which lowers blood pressure.
Hydrochlorothiazide is a diuretic that helps prevent the body from absorbing too much salt, which can cause fluid retention. It increases the amount of urine passed, which helps to lower blood pressure.
Side effects[edit | edit source]
Common side effects of valsartan/hydrochlorothiazide include dizziness, lightheadedness, and dehydration. Serious side effects may include fainting, muscle weakness, and changes in the amount of urine. Patients are advised to report any severe side effects to their healthcare provider.
Contraindications[edit | edit source]
Valsartan/hydrochlorothiazide is contraindicated in patients with anuria or hypersensitivity to any component of the product. It should not be used during pregnancy as it can harm the fetus.
Interactions[edit | edit source]
This medication may interact with other drugs, including lithium, NSAIDs, and other blood pressure medications. Patients should inform their healthcare provider of all medications they are taking to avoid potential interactions.
Related pages[edit | edit source]
References[edit | edit source]
Chemical structure of Valsartan
Chemical structure of Hydrochlorothiazide
Leukotriene B4 hydroxylation pathway
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