Thiazide diuretic

Thiazide diuretics are a type of diuretic often used to treat hypertension and edema. They work by inhibiting the sodium-chloride symporter in the distal convoluted tubule of the nephron in the kidney, which leads to an increase in the excretion of sodium, chloride, and water.

Mechanism of action

Thiazide diuretics inhibit the sodium-chloride symporter in the distal convoluted tubule of the nephron. This results in an increase in the excretion of sodium, chloride, and water, which in turn reduces the volume of fluid in the blood vessels, leading to a decrease in blood pressure.

Uses

Thiazide diuretics are primarily used in the treatment of hypertension. They can also be used to treat edema caused by heart failure, liver cirrhosis, and kidney disease.

Side effects

Common side effects of thiazide diuretics include hypokalemia, hyponatremia, hypercalcemia, and hyperglycemia. Less common side effects include gout, pancreatitis, and erectile dysfunction.

Examples

Examples of thiazide diuretics include hydrochlorothiazide, chlorthalidone, and indapamide.

See also

• Loop diuretic
• Potassium-sparing diuretic

Thiazide diuretic Resources
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