Spiraprilat

Spiraprilat is an ACE inhibitor used in the treatment of hypertension and congestive heart failure. It is the active metabolite of spirapril.

Pharmacology

Spiraprilat inhibits the angiotensin-converting enzyme (ACE), an enzyme that catalyzes the conversion of angiotensin I to the potent vasoconstrictor angiotensin II. By blocking this enzyme, spiraprilat reduces levels of angiotensin II, leading to decreased vasoconstriction and decreased release of aldosterone. This results in an overall decrease in blood pressure.

Clinical Use

Spiraprilat is used in the treatment of hypertension and congestive heart failure. It may be used alone or in combination with other antihypertensive agents.

Side Effects

Common side effects of spiraprilat include cough, dizziness, and hyperkalemia. Rare but serious side effects include angioedema and renal failure.

See Also

• ACE inhibitor
• Angiotensin II
• Hypertension
• Congestive heart failure

Spiraprilat Resources
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