Spiraprilat

Spiraprilat is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used primarily in the treatment of hypertension (high blood pressure) and congestive heart failure. It is the active metabolite of the prodrug spirapril, which is converted to spiraprilat in the body.

Mechanism of Action[edit]

Spiraprilat works by inhibiting the angiotensin-converting enzyme (ACE), which is responsible for the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor that increases blood pressure by causing blood vessels to narrow. By inhibiting ACE, spiraprilat decreases the production of angiotensin II, leading to vasodilation and a subsequent reduction in blood pressure.

Pharmacokinetics[edit]

After oral administration of spirapril, it is rapidly absorbed and converted to spiraprilat in the liver. The bioavailability of spiraprilat is influenced by the presence of food, which can reduce its absorption. Spiraprilat is primarily excreted by the kidneys.

Clinical Uses[edit]

Spiraprilat is used in the management of:

Side Effects[edit]

Common side effects of spiraprilat include:

Cough
Hyperkalemia (elevated potassium levels)
Hypotension (low blood pressure)
Dizziness
Renal impairment

Contraindications[edit]

Spiraprilat is contraindicated in patients with:

Angioedema related to previous ACE inhibitor therapy
Pregnancy
Severe renal artery stenosis

Drug Interactions[edit]

Spiraprilat may interact with:

Diuretics
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Potassium supplements or potassium-sparing diuretics
Lithium

Monitoring[edit]

Patients on spiraprilat should be monitored for:

References[edit]

Common ACE inhibitors include the following:

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