Anoctamin 6

Anoctamin 6 (ANO6), also known as TMEM16F, is a protein that in humans is encoded by the ANO6 gene. It is a member of the anoctamin family of proteins, which are known to be involved in various cellular functions such as chloride transport and phospholipid scrambling.

Function

ANO6 is a calcium-activated non-selective ion channel that mediates calcium dependent chloride flux across the cell membrane. It is also involved in the regulation of phospholipid scrambling, a process which exposes phosphatidylserine on the cell surface and plays a role in blood coagulation.

Clinical significance

Mutations in the ANO6 gene have been associated with Scott syndrome, a rare bleeding disorder characterized by impaired platelet function. Additionally, ANO6 has been implicated in the progression of certain types of cancer, including breast cancer and prostate cancer.

See also

• Anoctamin
• TMEM16F
• Scott syndrome