Phosphatidylserine

Phosphatidylserine is a phospholipid and a component of the cell membrane. It plays a key role in cell cycle signaling, specifically in relationship to apoptosis.

Structure

Phosphatidylserine is a glycerophospholipid in which two fatty acids are attached in ester linkage to the first and second carbon of glycerol, and serine is attached through a phosphodiester linkage to the third carbon of the glycerol.

Role in apoptosis

Phosphatidylserine plays a key role in cell cycle signaling, particularly in relation to apoptosis. Early in apoptosis, phosphatidylserine is relocated from the inner side of the plasma membrane to the cell surface. This acts as a signal for macrophages to engulf the cells.

Dietary sources

Phosphatidylserine is found in meat and fish. Smaller amounts of phosphatidylserine can be found in dairy products or in vegetables, with the exception of white beans and soy lecithin.

Health benefits

Phosphatidylserine is thought to be beneficial for improving memory and cognitive function. It has been studied in relation to Alzheimer's disease, with some promising results.

See also

• Lipid
• Cell membrane
• Apoptosis
• Alzheimer's disease

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