Anterior olfactory nucleus

Anterior olfactory nucleus (AON) is a structure in the brain that is involved in the processing of olfactory information. It is part of the olfactory system, which is responsible for the sense of smell.

Anatomy

The anterior olfactory nucleus is located in the olfactory bulb, which is situated at the front of the brain. It is composed of several layers of cells, including mitral cells and tufted cells, which receive input from olfactory receptor neurons in the olfactory epithelium.

Function

The primary function of the anterior olfactory nucleus is to process olfactory information received from the olfactory receptor neurons. This information is then relayed to other areas of the brain, including the piriform cortex, the amygdala, and the hippocampus, where it is further processed and integrated into the perception of smell.

Clinical significance

Damage to the anterior olfactory nucleus can result in a loss of smell, a condition known as anosmia. This can occur as a result of traumatic brain injury, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, and certain infections.

Research

Research into the anterior olfactory nucleus has focused on its role in olfactory processing and its potential involvement in neurodegenerative diseases. Some studies have suggested that changes in the structure or function of the anterior olfactory nucleus may be an early indicator of diseases such as Parkinson's and Alzheimer's.

See also

• Olfactory system
• Olfactory bulb
• Anosmia