Antiprogestogens

Antiprogestogens are a class of drugs that block the effects of progestogens, or naturally occurring hormones in the body. They are used in a variety of medical applications, including the treatment of endometriosis, uterine fibroids, and as a part of some contraceptive methods.

Mechanism of Action

Antiprogestogens work by binding to the progesterone receptor and blocking its action. This prevents the effects of progestogens, which include the preparation of the endometrium for pregnancy and the maintenance of pregnancy.

Uses

Antiprogestogens are used in a variety of medical applications. They are used in the treatment of endometriosis and uterine fibroids, conditions that are often caused by an excess of progestogens. They are also used as a part of some contraceptive methods, where they prevent pregnancy by blocking the action of progestogens.

Side Effects

Like all drugs, antiprogestogens can have side effects. These can include nausea, vomiting, and bleeding. In rare cases, they can cause severe allergic reactions.

Examples

Examples of antiprogestogens include mifepristone and ulipristal acetate. Mifepristone is used in some forms of abortion, while ulipristal acetate is used in the treatment of uterine fibroids and as an emergency contraceptive.

See Also

• Progestogen
• Progesterone receptor
• Endometrium
• Endometriosis
• Uterine fibroids
• Contraceptive
• Mifepristone
• Ulipristal acetate

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