Antipsychotic ester

Antipsychotic ester is a type of antipsychotic medication that is chemically modified to form an ester. This modification is typically done to improve the medication's pharmacokinetic properties, such as its absorption, distribution, metabolism, and excretion.

Overview

Antipsychotic esters are a class of psychotropic drugs used primarily in the treatment of psychotic disorders, including schizophrenia, bipolar disorder, and psychotic depression. They work by blocking the action of certain chemicals in the brain, such as dopamine, which is thought to be overactive in people with these conditions.

Types of Antipsychotic Esters

There are several types of antipsychotic esters, including:

• Haloperidol decanoate: This is a long-acting form of haloperidol, a typical antipsychotic. It is administered by injection and is used primarily in the treatment of schizophrenia and other psychotic disorders.

• Fluphenazine decanoate: This is a long-acting form of fluphenazine, another typical antipsychotic. It is also administered by injection and is used to treat schizophrenia.

• Paliperidone palmitate: This is a long-acting form of paliperidone, an atypical antipsychotic. It is used in the treatment of schizophrenia and schizoaffective disorder.

Pharmacokinetics

The esterification of antipsychotics results in a prodrug that is inactive until it is metabolized in the body. This process allows for a slower and more controlled release of the active drug, which can improve adherence to treatment and reduce the risk of side effects.

Side Effects

Like all antipsychotics, antipsychotic esters can cause side effects, including extrapyramidal symptoms, tardive dyskinesia, and neuroleptic malignant syndrome. They can also cause metabolic side effects, such as weight gain and increased risk of diabetes and cardiovascular disease.

See Also

• Antipsychotic
• Ester
• Psychotropic drug
• Psychotic disorder
• Schizophrenia
• Bipolar disorder
• Psychotic depression