Apararenone
A detailed overview of the drug Apararenone
Apararenone[edit | edit source]
Apararenone is a pharmaceutical compound classified as a mineralocorticoid receptor antagonist. It is primarily used in the treatment of conditions related to aldosterone excess, such as hypertension and heart failure.
Mechanism of Action[edit | edit source]
Apararenone functions by inhibiting the action of aldosterone, a hormone that increases the reabsorption of sodium and water in the kidneys. By blocking aldosterone, apararenone reduces sodium reabsorption, leading to decreased blood volume and lower blood pressure. This mechanism is beneficial in managing conditions like hypertension and heart failure, where fluid overload is a concern.
Pharmacokinetics[edit | edit source]
Apararenone is administered orally and is absorbed through the gastrointestinal tract. It undergoes hepatic metabolism and is excreted primarily through the kidneys. The drug has a half-life that allows for once-daily dosing, making it convenient for patients.
Clinical Uses[edit | edit source]
Apararenone is indicated for the treatment of:
Side Effects[edit | edit source]
Common side effects of apararenone include:
Patients are advised to monitor their potassium levels regularly due to the risk of hyperkalemia.
Related pages[edit | edit source]
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