Piretanide
(Redirected from Arelix)
Piretanide is a loop diuretic that is used in the treatment of hypertension and edema. It is a potent diuretic agent that increases the excretion of sodium and chloride ions in the kidney. Piretanide is chemically related to other loop diuretics such as furosemide and bumetanide.
Pharmacology[edit | edit source]
Piretanide acts on the ascending limb of the loop of Henle in the kidney, inhibiting the reabsorption of sodium and chloride ions. This results in an increase in the excretion of these ions, along with water, leading to a diuretic effect. The diuretic effect of piretanide is dose-dependent and is seen within one hour of oral administration.
Clinical Use[edit | edit source]
Piretanide is used in the treatment of edema associated with congestive heart failure, liver cirrhosis, and renal disease. It is also used in the treatment of hypertension. Piretanide may be used alone or in combination with other antihypertensive agents.
Side Effects[edit | edit source]
The most common side effects of piretanide are related to its diuretic action and include dehydration, hypotension, and electrolyte imbalance. Other side effects may include gastrointestinal disturbances, rash, and dizziness.
Contraindications[edit | edit source]
Piretanide is contraindicated in patients with known hypersensitivity to the drug or other sulfonamide-derived drugs. It is also contraindicated in patients with severe renal or hepatic impairment, and in patients with hypokalemia or hyponatremia.
Interactions[edit | edit source]
Piretanide may interact with other medications, including other diuretics, ACE inhibitors, angiotensin II receptor blockers, and nonsteroidal anti-inflammatory drugs (NSAIDs). These interactions can increase the risk of side effects or reduce the effectiveness of piretanide.
See Also[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD