Piretanide

Piretanide

Piretanide is a loop diuretic that is used in the treatment of hypertension and edema. It is a potent diuretic agent that increases the excretion of sodium and chloride ions in the kidney. Piretanide is chemically related to other loop diuretics such as furosemide and bumetanide.

Pharmacology

Piretanide acts on the ascending limb of the loop of Henle in the kidney, inhibiting the reabsorption of sodium and chloride ions. This results in an increase in the excretion of these ions, along with water, leading to a diuretic effect. The diuretic effect of piretanide is dose-dependent and is seen within one hour of oral administration.

Clinical Use

Piretanide is used in the treatment of edema associated with congestive heart failure, liver cirrhosis, and renal disease. It is also used in the treatment of hypertension. Piretanide may be used alone or in combination with other antihypertensive agents.

Side Effects

The most common side effects of piretanide are related to its diuretic action and include dehydration, hypotension, and electrolyte imbalance. Other side effects may include gastrointestinal disturbances, rash, and dizziness.

Contraindications

Piretanide is contraindicated in patients with known hypersensitivity to the drug or other sulfonamide-derived drugs. It is also contraindicated in patients with severe renal or hepatic impairment, and in patients with hypokalemia or hyponatremia.

Interactions

Piretanide may interact with other medications, including other diuretics, ACE inhibitors, angiotensin II receptor blockers, and nonsteroidal anti-inflammatory drugs (NSAIDs). These interactions can increase the risk of side effects or reduce the effectiveness of piretanide.

See Also

• Diuretic
• Hypertension
• Edema