Arginine vasopressin receptor 1A

Arginine vasopressin receptor 1A (AVPR1A) is a protein that in humans is encoded by the AVPR1A gene. It is a G protein-coupled receptor (GPCR) that binds the vasopressin hormone, playing a critical role in regulating the body's retention of water, vasoconstriction, and various social behaviors.

Function

AVPR1A is one of the receptors for arginine vasopressin (AVP), a hormone involved in maintaining water homeostasis in the body through its actions in the kidneys. It is also implicated in a range of social behaviors, including pair bonding and aggression. The receptor is expressed in several tissues, including the brain, liver, and kidney, and mediates vasopressin's effects by activating G protein signaling pathways.

Clinical Significance

Mutations in the AVPR1A gene have been associated with various disorders, including nephrogenic syndrome of inappropriate antidiuresis (NSIAD) and familial autosomal dominant nocturnal frontal lobe epilepsy. Additionally, variations in the AVPR1A gene have been linked to social behavior traits, such as autism spectrum disorders and monogamy in certain species.

Pharmacology

AVPR1A is a target for drugs that modulate vasopressin's effects in the body. Vaptans are a class of non-peptide, orally active antagonists of the vasopressin receptors, including AVPR1A, used in the treatment of hyponatremia.

See Also

• Vasopressin
• G protein-coupled receptor
• Hyponatremia