Arias-Stella reaction
A histopathological reaction in the endometrium
The Arias-Stella reaction is a histopathological change observed in the endometrium, typically associated with pregnancy. It is characterized by hypersecretory changes in the endometrial glands, which can be mistaken for endometrial hyperplasia or endometrial carcinoma. This reaction is named after the Peruvian pathologist Javier Arias-Stella, who first described it.
Histopathology[edit | edit source]
The Arias-Stella reaction is marked by several distinct histological features. The endometrial glands exhibit nuclear enlargement, hyperchromasia, and cytoplasmic vacuolation. These changes are due to the influence of high levels of human chorionic gonadotropin (hCG) and other hormones during pregnancy.
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The nuclei of the glandular cells may appear bizarre and atypical, with prominent nucleoli. The cytoplasm often shows vacuolation and may contain eosinophilic secretions. These changes can mimic those seen in endometrial carcinoma, making accurate diagnosis crucial to avoid unnecessary treatment.
Clinical Significance[edit | edit source]
The Arias-Stella reaction is most commonly associated with ectopic pregnancy, but it can also be seen in normal intrauterine pregnancies and molar pregnancy. It is important for pathologists to recognize this reaction to differentiate it from malignant conditions of the endometrium.
Differential Diagnosis[edit | edit source]
The differential diagnosis for the Arias-Stella reaction includes:
Accurate diagnosis relies on correlating the histopathological findings with clinical information, such as the presence of pregnancy and levels of hCG.
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Gallery[edit | edit source]
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Contributors: Prab R. Tumpati, MD
