Aristolochic acid

Aristolochic acid is a naturally occurring compound that is found in the plant species of the Aristolochia and Asarum families. It is known for its toxic and carcinogenic properties.

Overview

Aristolochic acid is a mixture of structurally related nitrophenanthrene carboxylic acids. It is found in several plants, but most commonly in the Aristolochia and Asarum species. These plants have been used in traditional medicines for centuries, but the acid is now known to be a potent carcinogen and nephrotoxin.

Toxicity

The toxicity of aristolochic acid is well documented. It is a potent nephrotoxin, meaning it can cause severe damage to the kidneys. It is also a powerful carcinogen, and has been linked to the development of urothelial cancer.

Medical Use

Despite its toxicity, aristolochic acid has been used in traditional medicine for centuries. It has been used to treat a variety of conditions, including gout, rheumatism, and skin infections. However, due to its toxic and carcinogenic properties, its use in medicine is now highly controversial and generally discouraged.

Regulation

Due to the health risks associated with aristolochic acid, many countries have implemented regulations to limit its use. In the United States, the Food and Drug Administration (FDA) has issued warnings about the dangers of aristolochic acid and has banned the importation of dietary supplements that contain it.

See Also

• Aristolochia
• Asarum
• Nephrotoxin
• Carcinogen
• Urothelial cancer
• Food and Drug Administration

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