Triamcinolone hexacetonide
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Triamcinolone hexacetonide is a synthetic glucocorticoid used primarily as an anti-inflammatory and immunosuppressant agent. It is a derivative of triamcinolone, a corticosteroid, and is known for its potent and long-lasting effects.
Medical Uses[edit | edit source]
Triamcinolone hexacetonide is commonly used in the treatment of various inflammatory conditions, including:
It is often administered via intra-articular injection directly into the affected joint to reduce inflammation and pain.
Mechanism of Action[edit | edit source]
As a glucocorticoid, triamcinolone hexacetonide works by inhibiting multiple inflammatory cytokines, thereby reducing inflammation and immune responses. It binds to the glucocorticoid receptor, which then translocates to the cell nucleus and modulates the expression of anti-inflammatory proteins while repressing the expression of pro-inflammatory proteins.
Pharmacokinetics[edit | edit source]
Triamcinolone hexacetonide is known for its slow absorption and prolonged duration of action, making it suitable for conditions requiring long-term anti-inflammatory effects. The drug is metabolized in the liver and excreted primarily via the kidneys.
Side Effects[edit | edit source]
Common side effects of triamcinolone hexacetonide include:
Long-term use can lead to more severe side effects, including adrenal suppression and immunosuppression.
Contraindications[edit | edit source]
Triamcinolone hexacetonide should not be used in patients with:
- Systemic fungal infections
- Known hypersensitivity to triamcinolone or any of its components
- Active infections without appropriate antimicrobial therapy
See Also[edit | edit source]
References[edit | edit source]
External Links[edit | edit source]
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