Arofylline

Arofylline

Arofylline is a pharmacological agent that belongs to the class of xanthine derivatives. It is primarily used as a bronchodilator in the treatment of asthma and chronic obstructive pulmonary disease (COPD).

Pharmacology

Arofylline works by inhibiting the enzyme phosphodiesterase, which leads to an increase in cyclic adenosine monophosphate (cAMP) in the smooth muscle cells of the bronchi. This results in relaxation of the bronchial muscles and dilation of the airways, thereby improving airflow and reducing symptoms such as shortness of breath and wheezing.

Clinical Use

Arofylline is used in the management of chronic respiratory conditions such as asthma and COPD. It is often used in combination with other medications, such as corticosteroids and beta2-adrenergic agonists, to provide optimal control of symptoms.

Side Effects

Like other xanthine derivatives, Arofylline can cause a range of side effects. These may include nausea, vomiting, abdominal pain, and insomnia. In rare cases, it can cause more serious side effects such as arrhythmia and seizures.

Contraindications

Arofylline is contraindicated in patients with a history of hypersensitivity to xanthine derivatives. It should also be used with caution in patients with peptic ulcer disease, seizure disorders, and certain heart conditions.

Drug Interactions

Arofylline may interact with a number of other medications, including certain antibiotics, antifungals, and antivirals. These interactions can affect the metabolism of Arofylline, potentially leading to increased levels of the drug in the body and an increased risk of side effects.

See Also

• Theophylline
• Doxofylline
• Xanthine