Atracurium besylate

Atracurium Besylate is a non-depolarizing neuromuscular-blocking drug or NMBD used primarily in the practice of anesthesia to induce muscle relaxation. It was initially introduced in the early 1980s and is part of the benzylisoquinolinium group of NMBDs.

Pharmacology

Atracurium Besylate acts as a competitive antagonist on the muscarinic acetylcholine receptor, specifically the subtype M2. It works by blocking the action of acetylcholine, a neurotransmitter that transmits signals in the nervous system. By doing this, Atracurium Besylate prevents muscle contractions and induces muscle relaxation.

Clinical Use

In the clinical setting, Atracurium Besylate is used to relax the muscles during surgery, particularly during procedures that require deep levels of muscle relaxation. It is also used in intensive care units to facilitate mechanical ventilation.

Side Effects

Like all drugs, Atracurium Besylate can cause side effects. These can include hypotension, slow heart rate, and skin reactions. In rare cases, it can cause severe allergic reactions.

Metabolism

Atracurium Besylate is metabolized in the body by a process called Hofmann elimination, which is temperature and pH dependent. This process does not require hepatic or renal function, making Atracurium Besylate a suitable choice for patients with impaired liver or kidney function.

See Also

• Neuromuscular-blocking drug
• Anesthesia
• Muscle relaxant
• Acetylcholine