Atracurium besilate

Atracurium besilate is a medication used in anesthesia to induce muscle relaxation. It is a non-depolarizing neuromuscular blocker and is administered intravenously.

Pharmacology[edit | edit source]

Atracurium besilate works by blocking the action of acetylcholine on the neuromuscular junction, thereby inhibiting the transmission of nerve impulses and causing muscle relaxation. It is a competitive antagonist of acetylcholine at the neuromuscular junction.

Uses[edit | edit source]

Atracurium besilate is used in anesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Side Effects[edit | edit source]

Possible side effects of atracurium besilate include hypotension, tachycardia, bronchospasm, and skin reactions. In rare cases, it can cause severe allergic reactions.

Contraindications[edit | edit source]

Atracurium besilate is contraindicated in patients with known hypersensitivity to the drug. It should be used with caution in patients with neuromuscular diseases, severe cardiovascular disease, or severe electrolyte disturbances.

Interactions[edit | edit source]

Atracurium besilate may interact with other drugs such as antibiotics, magnesium salts, lithium, local anesthetics, quinidine, and certain other neuromuscular blockers.

Dosage and Administration[edit | edit source]

The dosage of atracurium besilate is individualized and should be adjusted according to the patient's response and the duration of the procedure. It is administered intravenously, either as a bolus injection or as a continuous infusion.

See Also[edit | edit source]

Atracurium besilate Resources
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