Auvi-q

What is Auvi-q?

• Auvi-q contains (epinephrine), a non-selective alpha and beta-adrenergic receptor agonist used to treat life-threatening allergic reactions including anaphylaxis.

File:Auvi-Q Injection.webm

Epinephrine

Epinephrine ball-and-stick

What are the uses of this medicine?

• AUVI-Q is a prescription medicine used to treat life-threatening allergic reactions including anaphylaxis in people who are at risk for or have a history of serious allergic reactions.
• AUVI-Q is for immediate self (or caregiver) administration and does not take the place of emergency medical care. You should get emergency medical help right away after using AUVI-Q.

How does this medicine work?

• Epinephrine acts on both alpha and beta-adrenergic receptors.
• Through its action on alpha-adrenergic receptors, epinephrine lessens the vasodilation and increased vascular permeability that occurs during anaphylaxis, which can lead to loss of intravascular fluid volume and hypotension.
• Through its action on beta-adrenergic receptors, epinephrine causes bronchial smooth muscle relaxation and helps alleviate bronchospasm, wheezing and dyspnea that may occur during anaphylaxis.
• When given subcutaneously or intramuscularly, epinephrine has a rapid onset and short duration of action.

Who Should Not Use this medicine ?

• This medicine have no usage limitations.

What drug interactions can this medicine cause?

• Patients who receive epinephrine while concomitantly taking cardiac glycosides, diuretics, or anti-arrhythmics should be observed carefully for the development of cardiac arrhythmias
• Beta-adrenergic blocking drugs(eg: propranolol) may antagonize cardiostimulating and bronchodilating effects of epinephrine.
• Alpha-adrenergic blocking drugs(eg: phentolamine) may antagonize vasoconstricting and hypertensive effects of epinephrine.
• Ergot alkaloids may also reverse the pressor effects of epinephrine.
• Tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium, and certain antihistamines may potentiate effects of epinephrine.

Is this medicine FDA approved?

• Initial U.S. Approval: 1939

How should this medicine be used?

Recommended dosage:

• Patients greater than or equal to 30 kg (66 lbs): AUVI-Q 0.3 mg
• Patients 15 to 30 kg (33 to 66 lbs): AUVI-Q 0.15 mg
• Patients 7.5 to 15 kg (16.5 to 33 lbs): AUVI-Q 0.1 mg

Administration:

• Each AUVI-Q contains only 1 dose of medicine.
• AUVI-Q should only be injected into the muscle of your outer thigh. It can be injected through your clothing, if needed.
• Read the Instructions for Use at the end of this Patient Information Leaflet for information about the right way to use AUVI-Q.
• Use AUVI-Q exactly as your healthcare provider tells you to use it.
• A Trainer for AUVI-Q with a separate Trainer Instructions for Use leaflet is included with AUVI-Q.
• Practice with the Trainer for AUVI-Q before an allergic emergency happens to make sure you are able to safely use the real AUVI-Q in an emergency.
• The Trainer for AUVI-Q does not contain a needle or medicine and can be reused to practice your injection.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

• As Injection, 0.3 mg: 0.3 mg/0.3 mL epinephrine injection, USP, pre-filled auto-injector

Injection, 0.15 mg: 0.15 mg/0.15 mL epinephrine injection, USP, pre-filled auto-injector Injection, 0.1 mg: 0.1 mg/0.1 mL epinephrine injection, USP, pre-filled auto-injector

This medicine is available in fallowing brand namesː

• AUVI-Q

What side effects can this medication cause?

The most common side effects of this medicine include:

• fast, irregular, or ‘pounding’ heart beat
• sweating
• shakiness
• headache
• paleness
• feelings of over excitement, nervousness, or anxiety
• weakness
• dizziness
• nausea and vomiting
• breathing problems

AUVI-Q may cause serious side effects include:

• AUVI-Q should only be injected into your outer thigh. If you accidentally inject AUVI-Q into any other part of your body, go to the nearest hospital emergency room right away.

What special precautions should I follow?

• AUVI-Q is not intended as a substitute for immediate medical care. In conjunction with the administration of epinephrine, the patient should seek immediate medical or hospital care.
• Do not inject intravenously, into buttock, or into digits, hands, or feet.
• To minimize the risk of injection-related injury, instruct caregivers to hold the child’s leg firmly in place and limit movement prior to and during injection when administering to young children or infants.
• Rare cases of serious skin and soft tissue infections have been reported following epinephrine injection. Advise patients to seek medical care if they develop signs or symptoms of infection at the epinephrine injection site.
• Epinephrine is the preferred treatment for serious allergic reactions or other emergency situations even though this product contains sodium bisulfite, a sulfite that may, in other products, cause allergic-type reactions including anaphylactic symptoms or life-threatening or less severe asthmatic episodes in certain susceptible persons.
• Administer with caution in patients with heart disease; may aggravate angina pectoris or produce ventricular arrhythmias.

What to do in case of emergency/overdose?

Symptoms of overdosage may include:

• cerebrovascular hemorrhage
• pulmonary edema
• bradycardia
• tachycardia
• cardiac arrhythmia
• multifocal ventricular tachycardia
• atrial tachycardia
• atrioventricular block
• pallor
• coldness of the skin
• metabolic acidosis
• kidney failure

Management of overdosage:

• Treatment consists of rapidly acting vasodilators or alpha-adrenergic blocking drugs and/or respiratory support.
• Treatment of arrhythmias consists of administration of a beta-adrenergic blocking drug such as propranolol.

Can this medicine be used in pregnancy?

• There are no adequate and well controlled studies of the acute effect of epinephrine in pregnant women.

Can this medicine be used in children?

• AUVI-Q may be administered to pediatric patients at a dosage appropriate to body weight.
• It is not known if AUVI-Q is safe and effective in children who weigh less than 16.5 pounds (7.5 kg).

What are the active and inactive ingredients in this medicine?

• Active ingredient: epinephrine.
• Inactive Ingredients: sodium chloride, sodium bisulfite, hydrochloric acid, and water.

Who manufactures and distributes this medicine?

• Manufactured for:

Kaleo, Inc. Richmond, VA USA

What should I know about storage and disposal of this medication?

• Store AUVI-Q at 68° to 77°F (20° to 25°C).
• Do NOT expose to extreme heat or cold. For example, do NOT store in your vehicle’s glove box. Do not store AUVI-Q in the refrigerator or freeze.
• Examine contents in the viewing window periodically. Solution should be clear. If the solution is discolored (pinkish color or darker than slightly yellow), cloudy or contains solid particles, replace the unit.
• Your AUVI-Q has an expiration date. Replace it before the expiration date.
• Keep AUVI-Q in the outer case it comes in to protect it from light.

• Dailymed label info on Auvi-q
• FDA Auvi-q

Auvi-q Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.

Translate to: East Asian 中文, 日本, 한국어, South Asian हिन्दी, Urdu, বাংলা, తెలుగు, தமிழ், ಕನ್ನಡ,
Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, European español, Deutsch, français, русский, português do Brasil, Italian, polski