B16
B16 is a line of melanoma cells that are commonly used in medical research. These cells are derived from a spontaneous melanoma in a C57BL/6 mouse, and are used in a variety of studies, including those related to cancer immunotherapy, tumor microenvironment, and metastasis.
History[edit | edit source]
The B16 melanoma cell line was first established in the 1950s by R. L. Beattie and J. R. Pomerat. They derived the cell line from a spontaneous melanoma that developed in a C57BL/6 mouse. Since then, the B16 cell line has been used extensively in medical research, particularly in studies related to cancer immunotherapy and tumor microenvironment.
Characteristics[edit | edit source]
B16 cells are highly metastatic, which means they have the ability to spread from the primary site of the tumor to other parts of the body. This makes them a valuable tool in studying the process of metastasis. In addition, B16 cells are also highly immunogenic, which means they can stimulate an immune response. This characteristic makes them useful in studies related to cancer immunotherapy.
Use in Research[edit | edit source]
B16 cells are used in a variety of research studies. For example, they are often used in studies investigating the effectiveness of new cancer immunotherapies. In these studies, B16 cells are typically injected into mice, and the researchers then monitor the mice to see how their immune systems respond to the cancer cells.
In addition, B16 cells are also used in studies investigating the tumor microenvironment. These studies aim to understand how the environment surrounding a tumor can influence its growth and spread.
See Also[edit | edit source]
References[edit | edit source]
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