Tumor microenvironment

Tumor microenvironment is the immediate cellular environment in which a tumor exists, including surrounding blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix (ECM). The tumor microenvironment is dynamic and changes as the tumor grows and develops.

Overview[edit | edit source]

The tumor microenvironment is a complex and dynamic system that plays a crucial role in cancer progression and response to therapy. It is composed of various cell types including cancer cells, stromal cells, and immune cells, as well as non-cellular components such as the extracellular matrix and signaling molecules.

Components[edit | edit source]

Cancer cells[edit | edit source]

Cancer cells are the main component of the tumor microenvironment. They are characterized by uncontrolled growth and division, and the ability to invade other tissues.

Stromal cells[edit | edit source]

Stromal cells are non-cancerous cells that are part of the tumor microenvironment. They include fibroblasts, endothelial cells, and pericytes. These cells can support tumor growth and progression.

Immune cells[edit | edit source]

Immune cells in the tumor microenvironment can either promote or inhibit tumor growth. They include T cells, B cells, macrophages, and neutrophils.

Extracellular matrix[edit | edit source]

The extracellular matrix (ECM) is a network of proteins and carbohydrates that provides structural and biochemical support to cells. In the tumor microenvironment, the ECM can influence tumor growth and progression.

Role in cancer progression[edit | edit source]

The tumor microenvironment plays a crucial role in cancer progression. It can promote tumor growth, invasion, and metastasis, and can also influence the response to therapy.

See also[edit | edit source]

Tumor microenvironment Resources
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