BAPTA

BAPTA

BAPTA is a synthetic compound known for its ability to bind calcium ions. It is often used in biological research to manipulate calcium concentrations in a variety of experiments. BAPTA is an acronym for 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid.

History

BAPTA was first synthesized in the late 20th century as part of a series of compounds designed to selectively bind cations. Its development was a significant advancement in the field of biochemistry, as it allowed researchers to control and measure calcium concentrations in biological systems with unprecedented precision.

Structure and Properties

BAPTA is a chelating agent, meaning it can form multiple bonds with a single metal ion. In the case of BAPTA, it forms these bonds with calcium ions. The structure of BAPTA allows it to encapsulate the calcium ion, effectively removing it from solution.

Uses

BAPTA is primarily used in biological research. It is often used to control calcium concentrations in cells during experiments. By binding to calcium ions, BAPTA can prevent them from participating in biological reactions, allowing researchers to study the effects of reduced calcium concentrations.

In addition to its use in research, BAPTA has also been used in medical applications. For example, it has been used to treat conditions related to abnormal calcium levels in the body, such as hypercalcemia.

See Also

• EDTA
• EGTA
• Chelation therapy