BATF (gene)

BATF (gene)

The BATF gene, or Basic Leucine Zipper ATF-Like Transcription Factor, is a gene that encodes a protein in humans. This protein is a member of the AP-1/ATF superfamily of transcription factors. The encoded protein inhibits transcription by binding to a consensus sequence in the promoters of a variety of genes. This protein is believed to be a tumor suppressor and is critical for the response of immune cells to external signaling. Mutations in this gene may be involved in the pathogenesis of some cancers.

Location of the BATF gene on chromosome 14.

Structure

The BATF gene is located on the 14th chromosome, specifically at 14q24.3. It spans approximately 6.5 kilobases and contains four exons. The encoded protein is composed of 125 amino acids and has a predicted molecular weight of approximately 14 kDa.

Function

The BATF protein is a transcription factor that binds to the AP-1 site in the promoter regions of its target genes. It is involved in the regulation of immune responses and cell differentiation. It plays a crucial role in the development of T cells, B cells, and dendritic cells. It is also involved in the regulation of inflammation and autoimmune diseases.

Clinical Significance

Mutations in the BATF gene have been associated with various diseases. For instance, it has been linked to rheumatoid arthritis, systemic lupus erythematosus, and psoriasis. It is also implicated in certain types of cancer, including leukemia and lymphoma.

Research

Research on the BATF gene is ongoing, with studies focusing on its role in immune response, inflammation, and cancer. Understanding the function of this gene could lead to new treatments for a variety of diseases.

See Also

• Transcription factor
• Gene
• Chromosome 14
• Immune response
• Cancer