BAY-1024767
A detailed overview of the investigational drug BAY-1024767
BAY-1024767 is an investigational pharmaceutical compound developed by Bayer AG. It is primarily studied for its potential therapeutic effects in the treatment of cardiovascular diseases, particularly those involving the regulation of blood pressure and heart rate.
Mechanism of Action[edit | edit source]
BAY-1024767 is classified as a soluble guanylate cyclase (sGC) stimulator. Soluble guanylate cyclase is an enzyme found in the smooth muscle cells of blood vessels and plays a crucial role in the nitric oxide (NO) signaling pathway. When activated, sGC catalyzes the conversion of guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP), a secondary messenger that induces vasodilation and reduces blood pressure.
Mechanism:
- BAY-1024767 directly stimulates sGC, leading to increased levels of cGMP.
- The elevated cGMP levels result in relaxation of vascular smooth muscle, causing vasodilation.
- This process ultimately leads to a reduction in systemic vascular resistance and blood pressure.
Clinical Development[edit | edit source]
BAY-1024767 has undergone various phases of clinical trials to evaluate its safety, efficacy, and pharmacokinetics. The primary focus of these studies has been on its application in conditions such as pulmonary hypertension and heart failure.
Clinical Trials:
- Phase I Trials: Initial studies focused on assessing the safety profile and pharmacokinetics of BAY-1024767 in healthy volunteers.
- Phase II Trials: These trials aimed to evaluate the efficacy of BAY-1024767 in patients with specific cardiovascular conditions, such as pulmonary arterial hypertension (PAH).
Potential Applications[edit | edit source]
The primary therapeutic application of BAY-1024767 is in the management of cardiovascular diseases, particularly those characterized by elevated blood pressure and vascular resistance.
Applications:
- Treatment of pulmonary arterial hypertension (PAH)
- Management of chronic heart failure
- Potential use in other forms of systemic hypertension
Safety and Side Effects[edit | edit source]
As with any investigational drug, the safety profile of BAY-1024767 is a critical aspect of its clinical evaluation. Common side effects observed in clinical trials include:
- Headache
- Dizziness
- Hypotension (low blood pressure)
Regulatory Status[edit | edit source]
As of the latest updates, BAY-1024767 is still under investigation and has not yet received approval from major regulatory bodies such as the U.S. Food and Drug Administration (FDA) or the European Medicines Agency (EMA).
Also see[edit | edit source]
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Contributors: Prab R. Tumpati, MD