BD-1060

BD-1060 is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 9 ± 1 nM for the sigma-1 receptor, and 702 ± 147 nM for the sigma-2 receptor. It has been used in scientific research to explore the function of sigma receptors in the brain and other tissues.

Pharmacology

BD-1060 is a sigma receptor antagonist, meaning it blocks the activity of sigma receptors. Sigma receptors are a type of protein found in various tissues, but primarily in the brain. They are thought to be involved in a variety of physiological processes, including the regulation of mood, pain perception, and the response to stress.

BD-1060 has a high affinity for the sigma-1 receptor subtype, and a much lower affinity for the sigma-2 receptor subtype. This makes it a useful tool for studying the role of sigma-1 receptors in particular.

Research Uses

BD-1060 has been used in a variety of research contexts. For example, it has been used to investigate the role of sigma-1 receptors in the action of certain antidepressant and antipsychotic drugs. It has also been used to study the potential involvement of sigma-1 receptors in conditions such as schizophrenia, depression, and neuropathic pain.

Potential Therapeutic Applications

While BD-1060 itself is not used therapeutically, research into its effects could potentially lead to the development of new treatments for a variety of conditions. For example, if sigma-1 receptors are found to play a significant role in depression, drugs that modulate these receptors could potentially be developed as new antidepressants.

See Also

• Sigma receptor
• Sigma-1 receptor
• Sigma-2 receptor

References

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